Research Projects

Center of Biomedical Research Excellence

Project 1

Led by Dr. Bradley Ferguson, Ph.D., assistant professor of nutrition at the University of Nevada, Reno's College of Agriculture Biotechnology and Natural Resources, Project 1 focuses on research to identify epigenetic and non-epigenetic mechanisms that control cardio-metabolic diseases. Project 1 will explore the role of sarcomere protein acetylation which functions to regulate muscle contraction in the heart and prolonged heart enlargement. This research has the potential to develop different therapies for patients with heart failure due to cardiovascular diseases.

Project 2

Led by Dr. Haifeng Zheng, Ph.D., research assistant professor of physiology and cell biology at the University of Nevada, Reno, Project 2 focuses on mechanisms that regulate cardiac pacemaker activity and heart rate. Abnormal cardiac pacing can potentially lead to serious health problems. The research for this project explores the development of possibly new novel therapeutic targets for cardiac pacemaker deficiencies as well as the hypotheses about the origin and cause of atrial fibrillation in the heart.

Project 3

Led by Dr. Shailesh Agarwal, Ph.D., research assistant professor of Pharmacology at the University of Nevada, Reno, Project 3 focuses on nanoscale cell signaling in heart muscle cells. The research for this project aims to study the regulation of cAMP signaling by mitochondria-associated spaces that could lead to a better understanding of the cardiovascular system and physiology of the heart to develop novel therapeutic approaches for treating cardiovascular diseases.

Project 4

Led by Dr. Cam Ha Tran, Ph.D., assistant professor of Physiology and Cell Biology at the University of Nevada, Reno, Project 4 focuses on blood flow regulation in the brain. The research for this project explores how the different signaling pathways are integrated to regulate blood flow to the brain for the development of novel treatments for neurological disorders.