Brian Perrino Ph.D.: Experience/Publications

Associate Professor

Cellular and Molecular Pharmacology & Physiology | Department of Physiology and Cell Biology

Selected publications

2015

  • An C, Bhetwal BP, Sanders KM, Somlyo AV, Perrino BA. . Telokin phosphorylation and modulation of murine gastric fundus smooth muscle mechanical responses. manuscript under review, PLoS One.

2014

  • Sanders KM, Salter, AK, Hennig GW, Koh SD, Perrino BA, Ward, SM, and Baker, SA. . Responses to enteric motor neurons in the gastric fundus of mice with reduced intramuscular interstitial cells of Cajal. Journal of Neurogastroenterology and Motility. 20:171-84.

2013

  • Bhetwal BP, Sanders KM, An C, Trappanese DM, Moreland RS, Perrino BA. . Ca2+ sensitization pathways accessed by cholinergic neurotransmission in the murine gastric fundus. Journal of Physiology. 591.12:2971-86. Editor’s choice.
  • Bhetwal BP, An C, Baker SA, Lyon KL, Perrino BA. . Impaired contractile responses and altered expression and phosphorylation of Ca2+ sensitization proteins in gastric antrum smooth muscles from ob/ob mice. The Journal of Muscle Research and Cell Motility. 34(2):137-49.

2012

  • Fu K, Mende Y, Bhetwal BP, Baker S, Perrino BA, Wirth B, Fisher SA. . Tra2β protein is required for tissue specific splicing of a smooth muscle myosin phosphatase targeting subunit alternative exon. Journal of Biological Chemistry. 287(20):16575-85.

2011

  • Bhetwal BP, An CL, Fisher SA, Perrino BA. . Regulation of basal LC20 phosphorylation by MYPT1 and CPI-17 in murine gastric antrum, gastric fundus, and proximal colon smooth muscles. Neurogastroenterology & Motility. 23(10):e425-36.
  • Perrino BA. . Regulation of gastrointestinal motility by Ca2+/calmodulin-stimulated protein kinase II. Archives of Biochemistry and Biophysics. 510(2):174-81.

2010

  • Qureshi S, Song J, Lee HT, Koh SD, Hennig GW, Perrino BA. . CaM kinase II in colonic smooth muscle contributes to dysmotility in murine DSS-colitis. Neurogastroenterology & Motility. 22(2):186-95, e64.

2009

  • Orie NN, Thomas AM, Perrino BA, Tinker A, Clapp LH. . Ca2+/calcineurin regulation of cloned vascular K ATP channels: crosstalk with the protein kinase A pathway. British Journal of Pharmacology. 157(4):554-64.
  • Ayon R, Sones W, Forrest AS, Wiwchar M, Valencik ML, Sanguinetti AR, Perrino BA, Greenwood IA, Leblanc N. . Complex phosphatase regulation of Ca2+-activated Cl-currents in pulmonary arterial smooth muscle cells. Journal of Biological Chemistry. 284(47):32507-21.

2008

  • Kim M, Hennig GW, Park K, Han IS, Smith TK, Koh SD, Perrino BA. . Modulation of murine gastric antrum smooth muscle STOC activity and excitability by phospholamban. Journal of Physiology. 586 (Pt20): 4977-91.
  • Kim M, Hennig GW, Smith TK, Perrino BA. . Phospholamban knockout increases CaM kinase II activity and intracellular Ca2+ wave activity and alters contractile responses of murine gastric antrum. Cell Physiology - American Journal of Physiology. 294(2):C432-41.
  • Chen J, Chen H, Sanders KM, Perrino BA. . Regulation of SRF/CArG-dependent gene transcription during chronic partial obstruction of murine small intestine. Neurogastroenterology & Motility. 20(7):829-42. [ Editorial Viewpoint: MacDonald JA. 2008. Smooth muscle phenotypic plasticity in mechanical obstruction of the small intestine. Neurogastroenterology & Motility. 20(7): 737-40. ].

2007

  • Kim, M., and Perrino, B.A. . CaM kinase II activation and phospholamban phosphorylation by SNP in murine gastric antrum smooth muscles. American Journal of Physiology-Gastrointestinal and Liver Physiology. 292.g1045-54.
  • Jabr, R.I., R.I., Wilson, A.J., Riddervold, M.H., Jenkins, A.H., Perrino, B.A., and Clapp. . Nuclear translocation of calcineurin Ab but not Aa by platelet-derived growth factor in rat aortic smooth muscle. American Journal of Physiology - Cell Physiology. 292:C2213-25.

2006

  • Gary-Gouy, H., Sainz-Perez, A., Bismuth, G., Ghadiri, A., Perrino, B.A., and Dalloul, A. . Cyclosporin-A inhibits ERK phosphorylation in B cells by modulating the binding of Raf protein to Bcl2. Biochemical and Biophysical Research Communications 344:134-139.
  • Hicks, G., Perrino, B.A., Marrion, N.V. . Inhibition of BKCa channel activity by association with calcineurin in rat brain. European Journal of Neuroscience. 24:433-41.
  • Kim, M., Han, I.S., Koh, S.D., and Perrino, B.A. . Role of CaM kinase II and phospholamban in SNP-induced relaxation of murine gastric fundus smooth muscle. The American Journal of Physiology - Cell Physiology. 291: C337-47.

2005

  • Kim, M., Cho, S.Y., Han, I.S., Koh, S.D., and Perrino, B.A. . CaM kinase II and phospholamban contribute to caffeine-induced relaxation of murine gastric fundus smooth muscle. American Journal of Physiology - Gastrointestinal and Liver Physiology. 288:C1202-C1210.
  • Leblanc, N., Ledoux, J., Saleh, S., Sanguinetti, A., Angermann, J., O’Driscoll, K., Britton, F., Perrino, B.A., and Greenwood, I.A. . Regulation of Calcium-Activated Chloride Channels in Smooth Muscle Cells–A Complex Picture Is Emerging. Canadian Journal of Physiology and Pharmacology. 83:541-546.
  • Sergeant, G.P., Ohya, S., Rehill, J.R., Perrino, B.A., Koh, S.D., Sanders, K.M., and Horowitz, B. . Regulation of Kv4.3 channels by Ca2+/calmodulin-dependent protein kinase II. The American Journal of Physiology - Cell Physiology. 288:C304-C313.

2004

  • Greenwood, I.A., Ledoux, J., Perrino, B.A., and Leblanc, N. . Calcineurin-dependent dephosphorylation augments IClCa in pulmonary artery smooth muscle cells. Journal of Biological Chemistry. 279:38830-38837.

2002

  • Riddervold, M.H., Lorenz, J.M., Beckett, E.A.H., Baker, S.A., and Perrino, B.A. . Differential autophosphorylation of Ca2+/calmodulin-dependent protein kinase II from phasic and tonic smooth muscle tissues. American Journal of Physiology - Cell Physiology. 283: C1399-C1413.
  • Perrino, B.A., Wilson, A.J., Ellison, P., and Clapp, L.H. . Substrate selectivity and sensitivity to inhibition by immunophilin/immunosuppressant complexes of calcineurin heterodimers composed of the ? or ? catalytic subunit. European Journal of Biochemistry. 269:3540-3548.

2001

  • Martin, B.A.; Oxhorn, B.C.; Rossow, C.R.; and Perrino, B.A. . A cluster of basic residues in calcineurin B participates in the binding of calcineurin to phosphatidylserine vesicles. Journal of Biochemistry. (Tokyo)129:843-849.
  • Perrino, B.A. and Martin, B.A. . Ca2+-and myristoylation-dependent association of calcineurin with phosphatidylserine. Journal of Biochemistry. (Tokyo)129:835-841.
  • Amberg, G., Koh, S.D., Perrino, B.A., Hatton, W.J., and Sanders, K.M. . Regulation of A-type potassium channels in murine colonic myocytes by phosphatase activity. American Journal of Physiology - Cell Physiology. 281:C2020-2028.

2000

  • Perrino, B.A. . Regulation of calcineurin-dependent signaling pathways by protein targeting. Recent Research Developments in Endocrinology. 1:209-232.

1999

  • Koh, S. D.; Perrino, B. A.; Hatton, W. J.; Kenyon, J. L.; and Sanders, K. M. . Novel regulation of the A-type current in murine proximal colon by calcium/calmodulin-dependent protein kinase II. Journal of Physiology. 517 (Part1):75-84.
  • Perrino, B.A. . Regulation of calcineurin phosphatase activity by its autoinhibitory domain. Archives of Biochemistry and Biophysics. 372:159-165.

1998

  • Perrino, B.A. and Soderling, T.R. . Biochemistry and Pharmacology of the Calmodulin-Regulated Phosphatase Calcineurin. Invited chapter for “Calmodulin and Signal Transduction”, Academic Press, Eds: Linda van Eldik and D. Martin Watterson. 169-236.

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