Christine Cremo Ph.D.: Experience/Publications


Department of Pharmacology

Selected publications


  • Jackson DR Jr, Webb M, Stewart TJ, Phillips T, Carter M, Cremo CR, Baker JE. . Sucrose increases the activation energy barrier for actin-myosin strong binding. Archives of Biochemistry and Biophysics. pii: S0003-9861(13)00386-X. doi: 10.1016/ [ePub ahead of print] PubMed PMID: 24370736.
  • Hong F, Facemyer KC, Carter MS, Jackson del R, Haldeman BD, Ruana N, Sutherland C, Walsh MP, Cremo CR, Baker JE. . Kinetics of myosin light chain kinase activation of smooth muscle myosin in an in vitro model system. Biochemistry. 52(47):8489-500. doi: 10.1021/bi401001x. ePub 2013 Nov 11. PubMed PMID: 24144337; PubMed Central PMCID: PMC3886827.
  • Webb M, Jackson del R Jr, Stewart TJ, Dugan SP, Carter MS, Cremo CR, Baker JE. . The myosin duty ratio tunes the calcium sensitivity and cooperative activation of the thin filament. Biochemistry. 52(37):6437-44. doi: 10.1021/bi400262h. ePub 2013 Sep 3. PubMed PMID: 23947752.
  • Stewart TJ, Jackson DR Jr, Smith RD, Shannon SF, Cremo CR, Baker JE. . Actin Sliding Velocities are Influenced by the Driving Forces of Actin-Myosin Binding. Cellular and Molecular Bioengineering. 6(1):26-37. PubMed PMID: 23606917; PubMed Central PMCID: PMC3627502.


  • Ni S, Hong F, Haldeman BD, Baker JE, Facemyer KC, Cremo CR. . Modification of interface between regulatory and essential light chains hampers phosphorylation-dependent activation of smooth muscle myosin. Journal of Biological Chemistry. 287(26):22068-79. doi: 10.1074/jbc.M112.343491. ePub 2012 May 1. PubMed PMID: 22549781; PubMed Central PMCID: PMC3381165.


  • Sich NM, O'Donnell TJ, Coulter SA, John OA, Carter MS, Cremo CR, Baker JE. . Effects of actin-myosin kinetics on the calcium sensitivity of regulated thin filaments. Journal of Biological Chemistry. 285(50):39150-9. doi: 10.1074/jbc.M110.142232. ePub 2010 Oct 2. PubMed PMID: 20889979; PubMed CentralPMCID: PMC2998111.
  • Hong F, Haldeman BD, Jackson D, Carter M, Baker JE, Cremo CR. . Biochemistry of smooth muscle myosin light chain kinase. Archives of Biochemistry and Biophysics. 510(2):135-46. doi: 10.1016/ ePub 2011 May 3. Review. PubMed PMID: 21565153; PubMed Central PMCID: PMC3382066.
  • Jung HS, Billington N, Thirumurugan K, Salzameda B, Cremo CR, Chalovich JM, Chantler PD, Knight PJ. . Role of the tail in the regulated state of myosin 2. Journal of Molecular Biology. 408(5):863-78. doi: 10.1016/j.jmb.2011.03.019. ePub 2011 Mar 23. PubMed PMID: 21419133; PubMed Central PMCID: PMC3776433.
  • Vileno B, Chamoun J, Liang H, Brewer P, Haldeman BD, Facemyer KC, Salzameda B, Song L, Li HC, Cremo CR, Fajer PG. . Broad disorder and the allosteric mechanism of myosin II regulation by phosphorylation. Proceedings of the National Academy of Sciences U.S.A. 108(20):8218-23. doi: 10.1073/pnas.1014137108. ePub 2011 May 2. PubMed PMID: 21536903; PubMed Central PMCID: PMC3100986.
  • Milton DL, Schneck AN, Ziech DA, Ba M, Facemyer KC, Halayko AJ, Baker JE, Gerthoffer WT, Cremo CR. . Direct evidence for functional smooth muscle myosin II in the 10S self-inhibited monomeric conformation in airway smooth muscle cells. Proceedings of the National Academy of Sciences. 108(4):1421-6. doi: 10.1073/pnas.1011784108. ePub 2011 Jan 4. PubMed PMID: 21205888; PubMed Central PMCID: PMC3029703.

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