Kathleen Keef: Experience/Publications

Professor: Emeritus

Cellular and Molecular Pharmacology & Physiology | Department of Physiology and Cell Biology

Selected publications


  • Cobine CA, Callaghan BP, Keef KD. . Role of L-type Calcium Channels and PKC in Active Tone Development in Rabbit Coronary Artery. American Journal of Physiology - Heart and Circulatory Physiology Electronic Publication ahead of print.


  • Callaghan B, Zhong J, Keef KD. . Signaling pathway underlying stimulation of L-type Ca2+ channels in rabbit portal vein myocytes by recombinant Gbetagamma subunits. American Journal of Physiology: Heart and Circulatory Physiology. 291:H2541-2546.
  • Ro S, Kang SH, Farrelly AM, Ordog T, Partain R, Fleming N, Sanders KM, Kenyon JL, Keef KD. . Template switching within exons 3 and 4 of KV11.1 (HERG) gives rise to a 5' truncated cDNA. Biochemical and Biophysical Research Communications. 345:1342-1349.


  • Lee H.K., Ro S, Keef K.D., Kim Y.H., Kim H.W., Horowitz B, Sanders K.M. . Differential expression of P2X-purinoceptor subtypes in circular and longitudinal muscle of canine colon. Neurogastroenterology & Motility. 17(4):575-84.


  • Callaghan, B., Koh, S.D. and Keef, K.D. . Muscarinic M2 receptor stimulation of Cav1.2b requires PI3K, PKC and c-Src. Circulation Research. 94(5):626-333.


  • Horiguchi, K., Keef, K.D. and Ward, S.M. . Distribution of interstitial cells of Cajal in the tunica muscularis of the canine rectoanal region. American Journal of Physiology. 284(5):G756-67.
  • Farrelly, A.M., S. Ro, B. Callaghan, N. Fleming, B. Horowitz, K.M. Sanders and K.D. Keef. . Expression and function of KCNH2 (HERG) in the human jejunum. American Journal of Physiology. 284(6):G883-95.
  • Mutafova-Yambolieva, V.N., O’Driscoll, K., Farrelly, A., Ward, S.M. and Keef, K.D. . Spatial localization and properties of pacemaker potentials in the canine rectoanal region. American Journal of Physiology. 284(5):G748-55.


  • Ward, S. M., Gershon, M. D., Bayguinov, J. R., Nelson, C., Keef, K.D. and Sanders, K.M. . Distribution of ICC and electrical activity in ganglionic and aganglionic colons of mice. American Journal of Physiology. 283: G445-G456.
  • Keef, K.D., Anderson, U., O’Driscoll, K., Ward, S.M. and Sanders, K.M. . Electrical activity induced by nitric oxide In canine colonic circular muscle. American Journal of Physiology. 282: G123-G129.
  • Tichenor, S.D., I. L.O. Buxton, P. Johnson, K. O’Driscoll, and Keef, K.D. . Excitatory motor innervation in the canine rectoanal region: role of changing receptor populations. British Journal of Pharmacology. 137: 1321-9.


  • Mutafova-Yambolieva, V.N. and Keef, K.D. . Frequency dependent a2-adrenoceptor mediated modulation of excitatory junction potentials in guinea-pig mesenteric artery. European Journal of Pharmacology. 411: 123-127.
  • Fukao, M., Mason, H.S., Kenyon, J.L., Horowitz, B and Keef, K.D. . Regulation of BKCa channels expressed in HEK293 cells by epoxyeicosatrienoic acid. Molecular Pharmacology. 59: 16-23.
  • Keef, K.D., Hume, JR and Zhong, J. . Regulation of cardiac and smooth muscle Ca2+ channels (CaV1.2a,b) by protein kinases. Invited Review, American Journal of Physiology. 281: C1743-C1756.
  • Zhong, J. Hume, J.R. and Keef, K.D. . ß-adrenergic stimulation of vascular L-type Ca2+ channels involves both G-protein as and ß subunits. Journal of Physiology. 531: 105-115.

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