Qi Chen M.D., Ph.D.: Experience/Publications

Assistant Professor of Physiology and Cell Biology

Department of Physiology and Cell Biology

Professional experience

  • 2015-present: Assistant Professor at University of Nevada, Reno School of Medicine
  • 2011-2015: Assistant Professor at Institute of Zoology, Chinese Academy of Sciences, Beijing, China

Selected publications

In Press

  • Zhang X*, Cozen AE*, Liu Y, Chen Q**, Lowe TM**. In Press. Small RNA Modifications: Integral to Function and Disease. Trends in Molecular Medicine.


  • Chen Q*#, Yan M*, Cao Z*, Li X*, Zhang Y*, Shi J*, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E#, Zhai Q#, Zhou Q#. . Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science. 351(6271):397-400. (-Highlighted in Science 2016, Nature Reviews Genetics 2016, Cell Metabolism 2016, Cell Research 2016, FASEB Journal 2016, Biology of Reproduction 2016, et.al).
  • Chen Q**, Yan W**, Duan E**. . Epigenetic inheritance of acquired traits via sperm RNAs and sperm RNA modifications. Nature Reviews Genetics. doi: 10.1038/nrg.106.
  • Shi J*, Zhang Y*, Chen Q**. . Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence. Environmental Epigenetics. 2 (2): dvw014.


  • Zhang Y*, Chen Q*, Zhang H*, Wang Q*, Rong L, Jin Y, Wang H, Ma T, Qiao J, Duan E. . Aquaporin-mediated excessive intrauterine fluid is a major contributor in hyper-estrogen induced aberrant embryo implantation. Cell Research, 25(1):139-42.
  • Shi J*, Chen Q**, Li X*, Zheng X*, Zhang Y, Qiao J, Tang F, Tao Y**, Zhou Q**, Duan E**. . Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq. Development, 15;142(20):3468-77. Highlighted in Development: Revisiting blastomere equality. Development 2015 142: e2002.


  • Zhang Y, Zhang Y, Shi J, Zhang H, Cao Z, Gao X, Ren W, Ning Y, Ning L, Cao Y, Chen Y, Ji W, Chen Z**, Chen Q**, Duan E**. . Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection. Journal of Molecular Cell Biology 6:172-174. Cover Story & Editor’s Recommendation: Characterization of serum-enriched tsRNAs.
  • Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q**, Duan E**, Wang H**. . Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Research, 24:925-942. Cover Story & Highlighted by: Rbpj links uterine transformation and embryo orientation. Cell Research (2014); 24:1031-1032.


  • Chen Q*, Zhang Y*, Elad D, Jaffa AJ, Cao Y, Ye X**, Duan E**. . Navigating the site for embryo implantation: Biomechanical and molecular regulation of intrauterine embryo distribution. Molecular Aspects of Medicine, 34:1024-42.


  • Peng H, Shi J, Zhang Y, Zhang H, Liao S, Li W, Lei L, Han C, Ning L, Cao Y, Zhou Q, Chen Q**, Duan E**. . A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm. Cell Research, 22: 1609-1612. Highlighted by: A load of small RNAs in the sperm - how many bits of hereditary information? Cell Research (2013);23:18-19.


  • Chen Q*, Peng H*, Lei L*, Zhang Y, Kuang H, Cao Y, Shi QX, Ma T, Duan E**. . Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration. Cell Research, 21: 922-933.
  • Chen Q, Duan EK. . Aquaporins in sperm osmoadaptation: an emerging role for volume regulation. Acta Pharmacologica Sinica, 32: 721-4.
  • Chen Q*, Zhang Y*, Peng H, Lei L, Kuang H, Zhang L, Ning L, Cao Y, Duan E**. . Transient β2-Adrenoceptor activation confers pregnancy loss by disrupting embryo spacing at implantation. The Journal of Biological Chemistry, 286: 4349-4356.


  • Chen Q, Peng H, Zhang Y, Lei L, Cao Y, Duan E. . Embryo implantation: a time for recalling and forwarding. Chinese Science Bulletin, 54:4083-93.
  • Chen Q*, Zhang Y*, Lu J, Wang Q, Wang S, Cao Y, Wang H, Duan E. . Embryo-uterine cross-talk during implantation: the role of Wnt signaling. Molecular Human Reproduction, 15: 215-221.

*equal contribution
**correspondence author

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