Terence Smith Ph.D.: Experience/Publications

Professor: Emeritus

Department of Physiology and Cell Biology

Selected publications

2014

  • Takanobu Okamoto, MacKenzie J. Barton, Grant W. Hennig, Grace C. Birch, Nathan Grainger, Robert D. Corrigan, Sang Don Koh, Kenton M. Sanders, Terence K. Smith. . Extensive projections of myenteric serotonergic neurons suggest they comprise the central processing unit in the colon. Neurogastroenterology & Motility. 20, 423-4.

2013

  • Heredia DJ, Gershon MD, Koh SD, Corrigan RD, Okamoto T, Smith TK. . Important role of mucosal serotonin in colonic propulsion and peristaltic reflexes: in vitro analyses in mice lacking tryptophan hydroxylase. The Journal of Physiology. 591(Pt 23):5939-57.

2012

  • Broadhead MJ, Bayguinov PO, Okamoto T, Heredia DJ & Smith TK. . Activation of enteric glial cells during the colonic migrating motor complex in the isolated murine large intestine. The Journal of Physiology 590(Pt 2): 335-50.
  • Bayguinov PO, Broadhead MJ, Okamoto T, Hennig GW & Smith TK. . Activity in varicosities between and during the colonic migrating motor complex in the isolated murine colon. Neurogastroenterology & Motility; 2012 24, e185–e201.
  • Feng C-Y, Corrigan R, Hennig GW, Smith TK & von Bartheld CS. . Analysis of Spontaneous and Nerve-Evoked Calcium Transients in Intact Extraocular Muscles in Vitro. Experimental Eye Research. 100: 73-85.
  • Okamoto T, Bayguinov PO, Broadhead MJ & Smith TK. . Ca2+ imaging of submucous neurons during the colonic migrating motor complex in the isolated murine large intestine. Neurogastroenterology & Motility; 24(8): 1365-2982.
  • Heredia DJ, Granger N, McCann C, Smith TK. . Insights from a novel model of slow transit constipation generated by partial outlet obstruction in the murine large intestine. American Journal of Physiology - Gastrointestinal and Liver Physiology. 303(9):G1004-16.

2010

  • Bayguinov PO, Hennig GW, Smith TK. . Ca2+ imaging of activity in ICC-MY during local mucosal reflexes and the colonic migrating motor complex in the murine large intestine. The Journal of Physiology 588.22: 4453–4474.
  • Bayguinov PO, Hennig GW, Smith TK. . Calcium activity in different classes of myenteric neurons underlying the migrating motor complex in the murine colon. The Journal of Physiology. 588, 399–421.
  • Heredia DJ, Dickson EJ, Bayguinov PO, Hennig GW, Smith TK. . Colonic elongation inhibits pellet propulsion and migrating motor complexes in the murine large bowel. The Journal of Physiology 588, 2919–2934.
  • Smith TK, Dickson EJ, Heredia DJ, Hennig GW, Bayguinov PO. . Controversies involving the role of 5-hydroxytryptamine (5-HT) in generating colonic migrating motor complexes: what is spontaneous? Gastroenterology 138: 659 –670.
  • Dickson EJ, Heredia DJ, Smith TK. . Critical role of 5-HT1A, 5-HT3 and 5-HT7 receptor subtypes in the initiation, generation and propagation of the murine colonic migrating motor complex. American Journal of Physiology. 299(1): G144-157.
  • Dickson EJ, Heredia DJ, Hennig GW, Smith TK. . The mechanisms underlying the generation of the colonic migrating motor complex in both wild-type and nNOS knockout mice. American Journal of Physiology 298(2): G222-322.

2009

  • Lee HT, Hennig GW, Park KJ, Bayguinov PO, Ward SM, Sanders KM, Smith TK. . Heterogeneities in ICC Ca2+ activity within canine large intestine. Gastroenterology 136:2226-2236.
  • Hennig GW, Spencer NJ, Jokela-Willis S, Lee H-T, Bayguinov PO, Ritchie LA, Ward SM, Smith TK, Sanders KM. . ICC-MY coordinate smooth muscle contractions in the murine small intestine. Neurogastroenterology & Motility. 22(50): e138-151.
  • Heredia DJ, Dickson EJ, Hennig GW, Lee HT, Bayguinov PO, Spencer NJ, Smith TK. . Localized release of 5-HT by a fecal pellet regulates migrating motor complexes in murine colon. Gastroenterology 136(4):1328-38.

2008

  • Baker S, Hennig G, Han J, Britton F, Smith TK & Koh SD. . Methionine and its derivatives increase bladder excitability by inhibiting stretch-dependent K+ channels. British Journal of Pharmacology. 153(6):1259-71.
  • Kim M, Hennig GW, Park K, Han IS, Smith TK, Koh SD, Perrino BA. . Modulation of murine gastric antrum smooth muscle STOC activity and excitability by phospholamban. The Journal of Physiology (London). 2008; 586(Pt 20):4977-91.
  • Kim M, Hennig GW, Kenyon JL, Smith TK & Perrino BA. . Phospholamban knockout affects contractile responses, CaM kinase II activity, and intracellular Ca2+ wave activity in murine gastric antrum. American Journal of Physiology - Cell Physiology. 294(2):C432-41.
  • Dickson EJ, Hennig GW, Heredia DJ, Lee HT, Bayguinov PO, Spencer NJ, Smith TK. . Polarized intrinsic neural reflexes in response to colonic elongation. The Journal of Physiology (London). 1;586(Pt 17):4225-40.

2007

  • Dickson, EJ, Spencer NJ, Bayguinov PO, Heredia DJ, Hennig GW, Smith TK. . An intrinsic occult reflex underlies accommodation and slow transit in the distal large bowel. Gastroenterology. 132(5):1912-24.
  • Lee H-T, Hennig GW, Fleming NW, Keef KD, Spencer NJ, Ward SM, Sanders KM & Smith TK. . Septal interstitial cells of Cajal conduct pacemaker activity to excite muscle bundles in human jejunum. Gastroenterology. 133(3):907-17.
  • Lee H-T, Hennig GW, Fleming NW, Keef KD, Spencer NJ, Ward SM, Sanders KM & Smith TK. . The mechanism and spread of pacemaker activity through myenteric interstitial cells of Cajal in human small intestine. Gastroenterology 132(5):1852-65.

2006

  • Spencer NJ, Hennig GW, Bayguinov P, Park KJ, Lee HT, Heredia DJ, Sanders KM, Smith TK. . Activation of neuronal circuitry and Ca2+ waves in longitudinal and circular muscle during colonic MMCs and the consequences of rectal aganglionosis in mice. American Journal of Physiology. 292(2):G546-55.
  • Reis, HR, Vanden Berghe P, Romano-Silva MA & Smith TK. . GABA-induced calcium signaling in cultured enteric neurons is reinforced by activation of cholinergic pathways. Neuroscience. 139(2):485-94.
  • Spencer NJ, Dickson EJ, Hennig GW, Smith TK. . Sensory elements within the circular muscle are essential for mechanotransduction of ongoing peristaltic reflex activity in guinea pig distal colon. The Journal of Physiology (London). 2006; 576:519-531.

2005

  • Costa M, Sanders KM, Schemann M, Smith TK, Cook IJ, de Giorgio R, Dent J, Grundy D, Shea-Donohue T, Tonini M, Brookes SJ; the Varenna Group. . A teaching module on cellular control of small intestinal motility. Neurogastroenterology & Motility. 2005 Oct;17 Suppl. 3:4-19.
  • Shea-Donohue T, Cook IJ, de Giorgio R, Tonini M, Dent J, Costa M, Grundy D, Sanders KM, Schemann M, Smith TK, Brookes SJ; the Varenna Group. . A teaching module on irritable bowel syndrome. Neurogastroenterology & Motility. 17 Suppl. 3:20-40.
  • Brookes SJ, Cook IJ, Costa M, de Giorgio R, Dent J, Grundy D, Sanders KM, Schemann M, Shea-Donohue T, Smith TK, Tonini M; the Varenna Group. . Education project for pathophysiology of gastrointestinal motility. Neurogastroenterology & Motility. 17 Suppl. 3:2-3.
  • Smith TK, Hennig GW, Spencer N. . Sensory transduction in the ENS. Physiological News 58: 1-3.
  • Spencer N, Hennig GW, Dickson E., Smith TK. . Synchronization of enteric neuronal firing during the murine colonic MMC. The Journal of Physiology (London). 564:829-47.

2004

  • Vanden Berghe P, Hennig GW, Smith TK. . Characteristics of intermittent mitochondrial transport in guinea pig enteric nerve fibers. American Journal of Physiology. 286(4):G671-82.
  • Spencer NJ, Smith TK. . Mechanosensory S-neurons rather than AH neurons appear to generate a rhythmic motor pattern in guinea-pig distal colon. The Journal of Physiology (London). 558(Pt 2):577-96.
  • Hennig GW, Hirst GD, Park KJ, Smith CB, Sanders KM, Ward SM, Smith TK. . Propagation of pacemaker activity in the guinea-pig antrum. The Journal of Physiology (London). 556.2, 585-599.

2003

  • Smith TK, Oliver GR, Hennig GW, Vanden Berghe P, Kang SH, Spencer N. . A smooth muscle tone-dependent stretch-activated migrating motor pattern in isolated guinea-pig distal colon. The Journal of Physiology (London). 551(Pt 3):955-69.
  • Kang SH, Vanden Berghe P & Smith TK. . Ca2+-activated Cl- current in cultured myenteric neurons from murine proximal colon. American Journal of Physiology. Cell 284(4):C839-C847.
  • Spencer NJ, Sanders KM, Smith TK. . Migrating motor complexes do not require electrical slow waves in the mouse small intestine. The Journal of Physiology (London). 15;553(Pt 3):881-93.
  • Spencer N, Hennig, G. W. & Smith TK. . Stretch-activated intrinsic neuronal pathways to the longitudinal and circular muscle in guinea-pig distal colon. American Journal of Physiology. 284(2):G231-G241.

2002

  • Spencer N, Hennig, G. W. & Smith TK. . A rhythmic motor pattern activated by circumferential stretch in guinea-pig distal colon. The Journal of Physiology (London). 545(Pt 2): 629-648.
  • Spencer N, Hennig, G. W. & Smith TK. . A rhythmic motor pattern activated by circumferential stretch in guinea-pig distal colon. The Journal of Physiology (London). 545(Pt 2):629-648.
  • Spencer N, Hennig, GW & Smith TK. . Electrical rhythmicity and spread of action potentials in longitudinal muscle of guinea-pig distal colon. American Journal of Physiology. 282(5):G904-17.
  • Vanden Berghe P, Kenyon JL & Smith TK. . Mitochondrial Ca2+ uptake regulates the excitability of myenteric neurons. Journal of Neuroscience. 22(16):6962-6971.
  • Hennig G., Smith CB & Smith TK. . Patterns of intracellular and intercellular calcium waves in longitudinal muscle of murine large intestine. The Journal of Physiology (London).545(Pt 2):629-648.

2001

  • Bush, TG, Spencer N, Watters N, Sanders KM, & Smith TK. . Effects of alosetron on spontaneous migrating motor complexes in murine small and large intestine in vitro. American Journal of Physiology 281: G974-G983.
  • Spencer N, Smith, CB & Smith TK. . Role of muscle tone in intestinal peristalsis in the guinea-pig small intestine. The Journal of Physiology (London). 530.2: 295-306.
  • Spencer NJ, Smith TK. . Simultaneous intracellular recordings from longitudinal and circular muscle during the peristaltic reflex in guinea-pig distal colon. The Journal of Physiology. 15;533(Pt 3):787-99.
  • Spencer N, Hennig, GW & Smith TK. . Spatial and temporal coordination of spontaneous junction potentials in circular muscle of guinea-pig distal colon. The Journal of Physiology (London). 535.2: 565-578.

2000

  • Vogalis, F., Hillsley, K. & Smith TK. . Diverse Ionic Currents and Electrical Activity of Cultured Myenteric Neurons from the Guinea Pig Proximal Colon. Journal of Neurophysiology. 83(3):1253-1263.
  • Vogalis, F. & Smith TK. . Functional innervation of the biliary sphincter of the guinea-pig revealed by anti-autonomic drugs. Journal of Autonomic Pharmacology. 20 (3): 177-183.
  • Stevens RJ, Publicover NG & Smith TK. . Propagation and neural regulation of calcium waves in circular and longitudinal muscle layers of guinea-pig small intestine. Gastroenterology, 118: 1-15.
  • Spencer N, Walsh M & Smith TK. . Purinergic and cholinergic neuro-neuronal transmission underlying evoked by mucosal stimulation in the guinea-pig small intestine. Journal of Physiology (London). 522(2):321-31.
  • Vogalis, F., Hillsley, K. & Smith TK. . Recording ionic events from cultured, DiI-labelled myenteric neurons in the guinea-pig proximal colon. Journal of Neuroscience Methods. 96(1):25-34.
  • Hillsley, K., Kenyon, J. & Smith TK. . Ryanodine sensitive stores regulate the excitability of myenteric AH neurons. Journal of Neurophysiology. 84(6): 2777-2785.
  • Bush, TG., Spencer N, Watters N, Sanders KM, & Smith TK. . Spontaneous migrating motor complexes occur in both terminal ileum and colon of the C57BL/6 mouse in vitro. Autonomic Neuroscience, 84: 162-168.

1999

  • Shuttleworth CWR & Smith TK. . Action potential-dependent calcium transients in myenteric S neurons of the guinea-pig ileum. Neuroscience, 92(2), 751-62.
  • Publicover NG, Smith TK & Stevens, RJ. . Fluorescent imaging of propagation of excitability in gastrointestinal muscles. In: Reporters, Dyes, and Instrumentation, 3600: 42-50. San Jose, California, Society SPIE Conference on Molecular Imaging of Photo-Optical Instrumentation Engineers, Washington, U.S.A.
  • Stevens RJ, Publicover NG & Smith TK. . Induction and regulation of Ca2+ waves by enteric neural reflexes. Nature, 399: 62-66.
  • Spencer N, Walsh M & Smith TK. . Is the “Law of the Intestine” obeyed in the guinea-pig small intestine. Journal of Physiology (London). 517.3, 889-98.
  • Spencer N, McCarron SL & Smith TK. . Sympathetic suppression of ascending and descending interneurons during the peristaltic reflex in the isolated guinea-pig distal colon. Journal of Physiology (London). 519 (2):539-50.
  • Smith TK, Burke, EP & Shuttleworth, CWR. . Topographical and electrophysiological characteristics of highly excitable S neurons in the myenteric plexus of guinea-pig ileum. The Journal of Physiology (London). 517.3: 817-830.

1998

  • Yamamoto Y, Liu J, Smith TK & Mittal, RK. . Distension related responses in the circular muscle of the human esophagus: an ultrasonographic study. American Journal of Physiology. 275(4 Pt 1):G805-811.
  • Smith TK & Lunam CA. . Electrical characteristics and responses to jejunal distension of neurons in Remak's juxta-jejunal ganglia of the domestic fowl. The Journal of Physiology (London). 510.2, 563-575.
  • Smith TK & McCarron, S. . Nitric oxide modulates cholinergic reflex pathways to the longitudinal and circular muscle in the isolated guinea-pig distal colon. The Journal of Physiology (London). 512.3, 893-906.
  • Smith TK & WJ Robertson. . Synchronous movements of the longitudinal and circular muscle during peristalsis in the isolated guinea-pig distal colon. The Journal of Physiology (London). 99.3, 773-786.

1997

  • Keef KD, Murray DC & Smith TK. . Modulation of canine colonic electrical and contractile activity by basal nitric oxide release. The Journal of Physiology (London). 499.3, 773-786.

1996

  • Smith TK. . An electrophysiological identification of intrinsic sensory neurons responsive to 5-HT applied to the mucosa that underlie peristalsis in the guinea-pig proximal colon. The Journal of Physiology (London). 495: 102P.
  • Lunam CA & Smith TK. . Morphology and projections of neurons in Remak’s nerve of the domestic fowl revealed by intracellular injection of biocytin. Cell and Tissue Research, 284, 215-222.

1994

  • Du C, Carl A, Smith TK, Khoyi M, Sanders KM & Keef KD. . Mechanism of cAMP induced hyperpolarization in canine colon. Journal of Pharmacology and Experimental Therapeutics. 268 (1): 208-215.

1993

  • Smith TK, Ward S, Zhang L, Buxton ILO, Gerthoffer WT, Sanders KM & Keef KD. . Beta-adrenergic stimulation of electrical and mechanical activity in canine colon: role of cyclic AMP. American Journal of Physiology. 264: G708-G715.
  • Mittal RK & Smith TK. . Is nitric oxide the non-cholinergic neurotransmitter responsible for lower esophageal sphincter relaxation? Gastroenterology, 104(2):656.

1992

  • Smith TK, Bornstein JC & Furness JB. . Convergence of reflex pathways excited by distension and mechanical stimulation of the mucosa onto the same myenteric neurons of the guinea-pig small intestine. Journal of Neuroscience. 12(4): 1502-1510.
  • Smith TK, Bywater RAR, Holman ME & Taylor GS. . Electrical responses of the muscularis externa to distension of the isolated guinea-pig distal colon. Journal of Gastrointestinal Motility. 4: 145-156.

1991

  • Smith TK, Bornstein JC & Furness JB. . Interaction between reflexes evoked by distension and by stimulation of the mucosa of the guinea-pig ileum. Journal of the Autonomic Nervous System, 34: 69-76.
  • Yuan S.-Y, Furness JF, Bornstein JC & Smith TK. . Mucosal compression elicits polarized reflexes and enhances responses of the circular muscle to distension in the small intestine. Journal of the Autonomic Nervous System. 35: 219-226.
  • Bornstein JC, Furness JB, Smith TK & Trussel DC. . Synaptic responses evoked by mechanical stimulation of the mucosa in morphologically characterized myenteric neurons of the guinea-pig ileum. Journal of Neuroscience, 11: 505-518.

1990

  • Smith TK, Bornstein JC & Furness JB. . Distension-evoked ascending and descending reflexes in the circular muscle of the guinea-pig ileum. Journal of the Autonomic Nervous System, 29: 203-218.

1989

  • Furness JB, Trussell DC, Pompolo S, Bornstein JC & Smith TK. . Calbindin neurons of the guinea-pig small intestine: quantitative analysis of their numbers and projections. Cell & Tissue Research, 260: 261-272.
  • Furness JB, Bornstein JC, Smith TK, Murphy R and Pompolo S. . Correlated functional and structural analysis of enteric neural circuits. Archives of Histology & Cytology, 52: 161-166.
  • Smith TK, Reed JB & Sanders KM. . Electrical pacemakers of the canine proximal colon are functionally innervated by inhibitory motor neurons. American Journal of Physiology, 256 (25): C466-C477.
  • Kobayashi S, Furness JB, Smith TK & Pompolo S. . Histological identification of the interstitial cells of Cajal in the guinea-pig small intestine. Journal of the Autonomic Nervous System, 52: 277-296.
  • Furness JB, Bornstein JC, Smith TK, Murphy R & Pompolo S. . Neuronal circuits in the enteric nervous system. In: Nerves and the Gastrointestinal Tract Ed. MV Singer and H. Goedell: Lister UK pp 3-10.
  • Murphy R, Bornstein JC, Furness JB, Shuttleworth CWR & Smith TK. . Neuro-transmitters in the GI tract. GI Reports 4(2).
  • Smith TK. . Spontaneous junction potentials and slow waves in the circular muscle of guinea-pig ileum. Journal of the Autonomic Nervous System, 27: 147-154.

1988

  • Smith TK, Furness JB, Costa M & Bornstein JC. . An electrophysiological study of the projections of motor neurons that mediate non-cholinergic excitation in the circular muscle of the guinea-pig small intestine. Journal of the Autonomic Nervous System, 22: 115 - 128.
  • Smith TK, Reed JB & Sanders KM. . Effects of membrane potential on electrical slow waves of the circular muscle of the canine proximal colon. American Journal of Physiology, 255 (25): C828-834.
  • Smith TK & Furness JB. . Reflex changes in the circular muscle activity elicited by stroking the mucosa: an electrophysiological analysis in the isolated guinea-pig ileum. Journal of the Autonomic Nervous System, 25: 205-218.

1987

  • Smith TK, Reed JB & Sanders KM. . Interaction of two electrical pacemakers in the circular muscle of the canine proximal colon. American Journal of Physiology, 252: C290-C299.
  • Smith TK, Reed JB & Sanders KM. . Origin and propagation of electrical slow waves in the circular muscle of canine proximal colon. American Journal of Physiology, 252 (21): C215-C224.

1986

  • Sanders KM & Smith TK. . Enteric neural regulation of slow waves in the circular muscle of the canine proximal colon. The Journal of Physiology (London), 377: 297-313.
  • Sanders KM & Smith TK. . Motor neurons of the submucous plexus regulate electrical activity of the circular muscle of the canine proximal colon. The Journal of Physiology (London), 380: 293-310.

Reviews

2015

  • Smith TK, Gershon MD. . Cross Talk: 5-HT is necessary for peristalsis. Journal of Physiology.

2014

  • Smith TK, Park KJ & Hennig GW. . Colonic migrating motor complexes, high amplitude propagating contractions, neural reflexes and the importance of neuronal and mucosal serotonin. Journal of Neurogastroenterology and Motility 20, 423-446.

2010

  • Smith TK, Bayguinov PO, Hennig GW. . Generation of complex neuronal behavior in a mammalian nervous system. Physiology News 80: 29-32.

2009

  • Dinning PG, Smith TK, Scott SM. . Pathophysiology of colonic causes of chronic constipation. Neurogastroenterology & Motility; 21(Suppl. 2), 20-30.

2007

  • Smith TK, Dickson EJ, Hennig GW, Bayguinov PO, Spencer NJ. . Colonic elongation activates an intrinsic reflex that underlies slow transit and accommodation. Physiological News 69: 33-35.
  • Smith TK, Spencer NJ, Hennig GW. . Recent advances in enteric neurobiology: mechanosensory interneurons. Neurogastroenterology & Motility. 9(11):869-78.

2005

  • Smith TK, Hennig GW, Spencer N. . Sensory transduction in the ENS. Physiological News 58: 1-3.

2004

  • Tack J, Smith TK. . Calcium imaging of gut activity. Neurogastroenterology & Motility 16 Suppl. 1:86-95.

2003

  • Smith TK, Kang SH, Vanden Berghe P. . Calcium channels in enteric neurons. Current Opinion in Pharmacology. 3(6):588-93.
  • Sanders, KM & Smith, TK. . Neural regulation of colonic motor function. In: Colonic Diseases, Ed. Timothy Koch, M.D., Humana Press, Inc. Ch 3, 35-52.

1995

  • Smith TK & McCallum RW. . Serotonin in intestinal peristalsis. (6: 219-240) Regulatory mechanisms in gastrointestinal function. Ed. Timothy Garginella, CRC Press (Cat. 9439).

1994

  • Smith TK & Sanders KM. . Motility of the large intestine. Textbook of Gastroenterology I. Eds. Yamada T, Alpers DH, Owyang C, Powell DW, Silverstein. Philadelphia, JB Lippincott Co. Ch 10, 234-261.

1990

  • Smith TK. . Analysis of reflex pathways in the enteric nervous system. Proceedings of the Australian Neuroscience Society 1: 34-35.
  • Bornstein JC, Furness JB & Smith TK. . The enteric nervous system, its role in control of motility. In: Nerves and the Gastrointestinal Tract Ed. MV Singer and H. Goedell: Lister UK. Ch1. 1-32.
  • Furness JB, Bornstein JC & Smith TK. . The normal structure of gastrointestinal innervation. Journal of Gastroenterology & Hepatology, 5: Suppl. 1: 1-9.

1989

  • Sanders KM & Smith TK. . Electrophysiology of colonic smooth muscle. In: The Gastrointestinal System II. Handbook of Physiology, American Physiological Society, Washington DC, Ed. JD Wood 1(6): 251-271.

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