Violeta Mutafova-Yambolieva M.D., Ph.D.: Experience/Publications

Professor

Cellular and Molecular Pharmacology & Physiology | Department of Physiology and Cell Biology

Selected publications

2016

  • Durnin L, Moreland N, Lees A and V Mutafova-Yambolieva. . A commonly-used ecto-ATPase inhibitor, ARL-67156, block degradation of ADP more that the degradation of ATP in murine colon. Neurogastroenterology and Motility, 28(9):1370-81.
  • Durnin L, Hayoz S, Corrigan RD, Yanez A, Koh SD and V Mutafova-Yambolieva. . Urothelial purine release during filling of murine and primate bladders. American Journal of Physiology Renal Physiology, 311(4):F708-F716.

2015

  • Mutafova-Yambolieva V and KM Sanders. . Appropriate experimental approach is critical for identifying neurotransmitter substances: application to enteric purinergic neurotransmission. American Journal of Physiology Gastrointestinal and Liver Physiology, 309(7):G608-609, 2015.

2014

  • Kurahashi M, Mutafova-Yambolieva V, Koh S D and K M Sanders. . Platelet-derived growth factor receptor α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles. American Journal of Physiology Cell Physiology, 307(6):C561-70.
  • Mutafova-Yambolieva VN and L Durnin. . The purinergic neurotransmitter revisited: a single substance or multiple players. Pharmacology & Therapeutics, 144(2):162-191.
  • Durnin L, Hwang SJ, Kurahashi M, Ward SM, Sasse KC, Sanders KM, V Mutafova-Yambolieva. . Uridine adenosine tetraphosphate (Up4A) is a novel neurogenic P2Y1 receptor activator in the gut. Proceedings National Academy of Sciences U S A 111(44):15821-6.

2013

  • Peri LE, Sanders KM, and V Mutafova-Yambolieva. . Differential expression of genes related to purinergic signaling in smooth muscle cells, PDGFRA-positive cells, and interstitial cells of Cajal in the murine colon. Neurogastroenterology & Motility, 25(9):e609-20.
  • Durnin L, Sanders KM and V Mutafova-Yambolieva. . Differential release of β-NAD+ and ATP upon activation of enteric motor neurons in primate and murine colons. Neurogastroenterology & Motility, 25(3):e194-204.
  • Durnin L, Sanders KM and V Mutafova-Yambolieva. . Differential release of β-NAD+ and ATP upon activation of enteric motor neurons in primate and murine colons. *Highlighted in: Neurogastroenterology: Colonic motor neurotransmission-is β-NAD+ in control? Smith K, Nature Reviews Gastroenterology & Hepatology; 10(2):64.

2012

  • Durnin L, Hwang SJ, Ward SM, Sanders KM, and VN Mutafova-Yambolieva. . Adenosine 5'-diphosphate-ribose (ADPR) is a neural regulator in primate and murine large intestine along with β-NAD+. Journal of Physiology; 590(Pt 8):1921-41.
  • Mutafova-Yambolieva VN. . Neuronal and extraneuronal release of ATP and NAD+ in smooth muscle. International Union of Biochemistry and Molecular Biology, 64(10):817-824.
  • Hwang SJ, Blair PJ, Durnin L, Mutafova-Yambolieva V, Sanders KM and SM Ward. . P2Y1 purinoreceptors are fundamental to inhibitory motor control of murine colonic excitability and transit. Journal of Physiology, 590(Pt 8):1957-72, 2012.
  • Hwang SJ, Blair PJ, Durnin L, Mutafova-Yambolieva V, Sanders KM and SM Ward. . P2Y1 purinoreceptors are fundamental to inhibitory motor control of murine colonic excitability and transit. *Comment in: Resolution and concordance in dissecting the compound inhibitory junction potential. King BF, Journal of Physiology; 590(Pt8): 1777-8.
  • Durnin L, Dai YP, Aiba I, CW Shuttleworth, Yamboliev IA, VN Mutafova-Yambolieva. . Release, neuronal effects and removal of extracellular β-nicotinamide adenine dinucleotide (β-NAD+) in the rat brain. European Journal of Neuroscience; 35(3):423-35.

2011

  • Durnin L, VN Mutafova-Yambolieva. . Cyclic ADP-ribose (cADPR) requires CD38 to regulate the release of adenosine 5'-triphosphate (ATP) in visceral smooth muscle. FEBS Journal; 271:3095-3108.
  • Hwang SJ, Durnin L, Dwyer L, Rhee PL, Ward SM, Koh SD, Sanders KM, and VN Mutafova-Yambolieva. . β-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons. Gastroenterology, 140: 608-617.e6.
  • Hwang SJ, Durnin L, Dwyer L, Rhee PL, Ward SM, Koh SD, Sanders KM, and VN Mutafova-Yambolieva. . β-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons. *Comment in: A new player in neuromuscular transmission in the gastrointestinal tract. Rodriguez-Tapia E, Galligan JJ. Gastroenterology. 140(2):397-400.

2009

  • Smyth LM, Yamboliev IA, VN Mutafova-Yambolieva. . N-type and P/Q-type calcium channels regulate differentially the release of noradrenaline, ATP and β-NAD in blood vessels. Neuropharmacology; 56(2):368-378.
  • Yamboliev IA, Smyth LM, Durnin L, Dai Y-P, VN Mutafova-Yambolieva. . Storage and secretion of β-NAD, ATP and dopamine in NGF-differentiated rat pheochromocytoma PC12 cells. European Journal of Neuroscience; 30:756-768.

2007

  • Mutafova-Yambolieva VN, Hwang SJ, Hap X, Chen H, Zhu MX, Wood JD, Ward SM, Sanders KM. . β-nicotinamide adenine dinucleotide is a new inhibitory neurotransmitter in visceral smooth muscle. Proceedings National Academy of Sciences USA; 104(41):16359-64.

2006

  • Bobalova J, VN Mutafova-Yambolieva. . Activation of the adenylyl cyclase-protein kinase A pathway facilitates neural release of β-nicotinamide adenine dinucleotide (β-NAD) in canine mesenteric artery. European Journal of Pharmacology; 536, 128-132.
  • Smyth LM, Breen LT, VN Mutafova-Yambolieva. . Nicotinamide adenine dinucleotide (NAD) is released from sympathetic nerve terminals via a botulinum neurotoxin A mediated mechanism in canine mesenteric artery. The American Journal of Physiology - Heart and Circulatory Physiology, 290(5), H1818-H1825.
  • Smyth LM, Breen LT, Yamboliev IA, VN Mutafova-Yambolieva. . Novel localization of CD38 in perivascular sympathetic nerve terminals. Neuroscience; 139 (4): 1467-1477.
  • Dai Y-P, Bongalon S, Tian H, Mutafova-Yambolieva V, IA Yamboliev. . Upregulation of profilin, cofilin-2 and LIMK2 in cultured pulmonary artery smooth muscle cells and in pulmonary arteries of monocrotaline-treated rats. Vascular Pharmacology; 44(5), 275-282.
  • Breen LT, Smyth LM, Yamboliev IA, VN Mutafova-Yambolieva. . β-NAD is a novel nucleotide released upon stimulation of nerve terminals in human urinary bladder detrusor muscle. American Journal of Physiology - Renal Physiology, 290(2), F486-F495.

2005

  • Yamboliev IA, VN Mutafova-Yambolieva. . PI3K and PKC contribute to membrane depolarization mediated by alpha2-adrenoceptors in the canine isolated mesenteric vein. BMC Physiology, 15, 5:9.

2004

  • Smyth LM, Bobalova J, Mendoza MG, Lew C, and VN Mutafova-Yambolieva. . Release of β-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder. Journal of Biological Chemistry, 279(47), 48893-48903.

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