William E. Courchesne Ph.D.: Experience/Publications

Associate Professor

Department of Microbiology and Immunology

Professional experience

  • Postdoctoral Fellow, University of California, Berkeley

Selected publications


  • Klukovich, R. and W. E. Courchesne. . Functions of Saccharomyces cerevisiae Ecm27p, a putative Na+/Ca2+ exchanger, in calcium homeostasis, carbohydrate storage and cell cycle reentry from the quiescent phase. Microbiological Research 186: 81–89.


  • Hejchman, E., K. Ostrowska, D. Maciejewska, J. Kossakowski, and W.E. Courchesne. . Synthesis and antifungal activity of derivatives of 2- and 3-benzofurancarboxylic acids. Journal of Pharmacology & Experimental Therapeutics. 343:380-388.


  • Courchesne, W.E., C. Vlasek, R. Klukovich, and S. Coffee. . Ethanol induces calcium influx via the Cch1-Mid1 transporter in Saccharomyces cerevisiae. Arch. Microbiol. 193:323–334.


  • Courchesne, W.E., M. Tunc, S. Liao. . Amiodarone induces stress responses and calcium flux mediated by the cell wall in S. cerevisiae. Ca. J. Microbiology, 55:288-303.


  • Courchesne, W.E. and S. Ozturk. . Amiodarone induces a caffeine-inhibited, MID1-dependent rise in free cytoplasmic calcium in S. cerevisiae. Mol. Micro., 47:223-234.


  • Cao, H., W.E. Courchesne, and C.C. Mastick. . A phosphotyrosine-dependent (PY) dihybrid yeast protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of CSK to caveolae. J. Biol. Chem. 277:8771-8774.
  • Courchesne, W.E. . Characterization of a novel, broad-based fungicidal activity for the antiarrhythmic drug Amiodarone. Journal of Pharmacology and Experimental Therapeutics. 300:195-199.


  • Copley, K.S., S.M. Alm, D.A. Schooley, and W.E. Courchesne. . Expression, processing, proteolysis and secretion of Manduca sexta diuretic hormone by Saccharomyces cerevisiae. Biochemical J. 330:1333-1340.
  • Dong, H. and W.E. Courchesne. . Use of a novel quantitative mating assay on the fungal pathogen Cryptococcus neoformans provides insight into signalling pathways responding to nutrients and temperature. Microbiology 144:1691-1697.


  • Dohlman, H.G., D. Ma, W.E. Courchesne and J. Thorner. . Sst2, a factor required for recovery from pheromone-induced cell cycle arrest in the yeast S. cerevisiae: Expression, co-localization and genetic interactions with Gpa1 (G-protein a subunit). Mol. Cell. Biol. 16: 5194-5209.
  • McCracken, A.A., I.V. Karpichev, J.E. Ernaga, E.D. Werner, A.G. Dillin, N.J. Shebib, and W.E. Courchesne. . Yeast mutants deficient in ER-associated degradation of the Z variant of alpha-1-protease inhibitor. Genetics 144: 1355-1362.


  • Tolkacheva, T., P. McNamara, E. Piekarz, and W.E. Courchesne. . Cloning of a Cryptococcus neoformans Gene, GPA1, Encoding a G-Protein a Subunit Homolog. Infection and Immunity 62: 2849-2856.


  • Courchesne, W.E., R. Kunisawa, and J. Thorner. . A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae. Cell 58:1107-1119.


  • Blumer, K.J., J.E. Reneke, W.E. Courchesne, and J. Thorner. . Functional domains of a peptide hormone receptor: the a-factor receptor (STE2 gene product) of the yeast Saccharomyces cerevisiae. Cold Spring Harbor Symposium on Quantitative Biology 53: 591-603.
  • Courchesne, W.E. and B. Magasanik. . Regulation of nitrogen assimilation in Saccharomyces cerevisiae: roles of the URE2 and GLN3 genes. Journal of Bacteriology. 170:708-713.
  • Reneke, J.E., K.J. Blumer, W.E. Courchesne, and J. Thorner. . The carboxyl-terminal segment of the yeast a-factor receptor is a regulatory domain. Cell 55: 221-234.


  • Courchesne, W.E. . Nitrogen regulation in Saccharomyces cerevisiae. Ph.D. thesis, Massachusetts Institute of Technology.


  • Courchesne, W.E. and B. Magasanik. . Ammonia regulation of amino acid permeases in Saccharomyces cerevisiae. Molecular and Cellular Biology (MCB) 3:672-683.


  • Kotewitz, M., E. Grzesiuk, W.E. Courchesne, R. Fisher, and H. Echols. . Purification and characterization of the integration protein specified by bacteriophage lambda. Journal of Biological Chemistry 255:2433-2439.

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