Yumei Feng Earley Ph.D., M.D.: Experience/Publications

Associate Professor

| Cellular and Molecular Pharmacology & Physiology | Department of Pharmacology | Department of Physiology and Cell Biology

Selected publications



  • Cooper SG, Trivedi DP, Yamamoto R, Worker CJ, Feng CY, Sorensen JT, Yang W, Xiong Z, and Feng Y. . Increased (pro)renin receptor in subfornical organ neurons in hypertensive humans. Am J Physiol Heart Circ Physiol, 314: H796-H804, 2018. PMCID: 5966774.
  • Romanick S, Ulrich C, Schlauch K, Hostler A, Payne J, Woolsey R, Quilici D, Feng Y, and Ferguson B. . Obesity-mediated regulation of cardiac protein acetylation: Parallel analysis of total and acetylated protein via TMT-tagged mass spectrometry. Bioscience Reports, July 30. Doi: 10.1042/BSR20180721, 2018. PMID: 30061171.
  • Trebak F, Li W, and Feng Y. . The neuronal (pro)renin receptor regulates deoxycorticosterone-induced sodium intake. Physiol Genomics, doi: 10.1152/physiolgenomics.00065, 2018. PMID: 30142028.
  • Peng H, Jensen DD, Li W, Sullivan MN, Buller SA, Worker CJ, Cooper SG, Zheng S, Earley S, Sigmund CD, and Feng Y. . Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system. Am J Physiol Heart Circ Physiol, 314: H580-H592, 2018. PMCID: 5899258.


  • Xu Q, Jensen DD, Peng H, and Feng Y. . The Critical role of the central nervous system (pro)renin receptor in regulation of systemic blood pressure. Pharmacology & Therepeutics, 164: 126-134, 2016 (Review). PMCID: 4942374.
  • Pitra S, Feng Y, and Stern JE. . Mechanisms underlying prorenin actions on hypothalamic neurons implicated in cardiometabolic control. Molecular Metabolism, 5: 858-868,2016.
  • Lu X, Wang F, Xu C, Soodvilai S, Peng K, Su J, Zhao L, Yang KT, Feng Y, Zhou S-F, Gustafsson J-A, and Yang T. . Soluble (pro)renin receptor via β-catenin enhances urine concentration capability: a target of liver X receptor. Proceedings of the National Academy of Sciences, 113: E189-8-1906, 2016.


  • Feng Y. . Ang II-independent prorenin/(pro)renin receptor signaling pathways in the central nervous system. American Journal of Physiology: Heart and Circulatory Physiology. 309: H731-3, 2015 PMID: 26209058 (Review).
  • Li W, Liu J, Saifudeen Z, and Feng Y. . Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein in DOCA-salt-induced hypertension. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 309: R138-147, 2015. PMID: 25994957.
  • Li W, Sullivan MN, Zhang S, Worker CJ, Xiong Z, Speth RC, and Feng Y. . Intracerebroventricular infusion of the (pro)renin receptor antagonist PRO20 attenuates neurogenic hypertension. Hypertension, 65:352-361, 2015. PMID: 25421983.
  • Sullivan MN, Gonzales AL, Pires PW, Bruhl A, Leo MD, Li W, Oulidi A, Boop FA, Feng Y, Jaggar JH, Welsh DG, and Earley S. . Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation. Science Signaling. 8: ra2, 2015. PMID: 25564678.
  • Li Y, Liu J, Li W, Brown A, Baddoo M, Li M, Carroll T, Oxburgh L, Feng Y, and Saifudeen Z. . P53 enables metabolic fitness and self-renewal of nephron progenitor cells. Development, 142: 1228-1241, 2015. PMID: 25804735.
  • Wang F, Lu X, Liu M, Feng Y, Zhou S-F, and Yang T. . Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of local renin-angiotensin system. BMC Medicine, 13: 278, 2015. PMID: 26554902.


  • Zubcevic J, Jun JY, Kim S, Perez PD, Afzal A, Shan Z, Li W, Santisteban MM, Yuan W, Febo M, Mocco J, Feng Y, Scott E, Baekey DM, and Raizada MK. . Altered inflammatory response is associated with an impaired autonomic input to the bone marrow in the SHR. Hypertension. 63: 542-50, 2014. PMID: 24366083.
  • Xia H, de Queiroz TM, Sriramula S, Feng Y, Johnson T, Mungrue IM, Lazartigues E. . Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 308: R370-8, 2015. PMID: 25519733.
  • Cao T, Li W, Seth D, Navar G, and Feng Y. . Brain-targeted (pro)renin receptor knockdown modulates body fluid homeostasis. Journal of Hypertension, 3: 160, DOI: 10.4172/2167-1095.1000160, 2014.
  • Li W, Peng H, Mehaffey EP, Kimball CD, Grobe JL, van Gool JMG, Danser AJH, Ichihara A, and Feng Y. . Neuron-specific (pro)renin receptor knockout prevents the development of salt-sensitive hypertension. Hypertension. 63: 316-23, 2014. PMID: 24246383.


  • Cao T and Feng Y. . (Pro)renin receptor and body fluid homeostasis. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 305 (2): R104-6, 2013. PMID: 23678024 (Review).
  • Peng H, Li W, Seth DM, Nair AR, Francis J, and Feng Y. . (Pro)renin receptor mediates both angiotensin II-dependent and -independent superoxide production in neuronal cells. PLoS One. 8 (3): e58339, 2013. PMID: 23516464.
  • Li W, Peng H, Seth DM, and Feng Y. . The prorenin and (pro)renin receptor: new players in the brain renin-angiotensin system. International Journal of Hypertension. 2012: 290635. 2012. PMID: 23316344 (Review).


  • Feng Y, Hans C, Mcllwain E, Varner KJ, and Lazartigues E. . Angiotensin-converting enzyme 2 over-expression in the central nervous system reduces angiotensin-II-mediated cardiac hypertrophy. PLoS One.7: e48910, 2012. PMID: 23155428.
  • Li W, Peng H, Cao T, Sato R, McDaniels SJ, Kobori H, Navar LG, and Feng Y. . Brain-targeted (pro)renin receptor knockdown attenuates angiotensin II-dependent hypertension. Hypertension. 59: 1188-1194, 2012. PMID: 22526255.


  • Xia H, Suda S, Bindom SA, Feng Y, Gurley SB, Seth DM, Navar LG and Lazartigues E. . ACE2-Mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function. PLoS One. 6(7): e22682. 2011. PMID: 21818366.
  • Prieto MC, Gonzalez-Villalobos RA, Botros FT, Martin VL, Pagan J, Sato R, Lara LS, Feng Y, Fernandez F, Kobori H, Casarini DE, and Navar LG. . Reciprocal changes in renal ACE/Ang II and ACE2/Ang 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats. American Journal of Physiology - Renal Physiology. 300 (3): F749-55. 2011. PMID: 21209009.


  • Feng Y, Xia H, Santos RA, Speth RC and Lazartigues E. . ACE2: a new target for neurogenic hypertension. Experimental Physiology. 95(5): 601-6, 2010. (Selected for the Cover) PMID: 19923158.
  • Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RA, Speth RC, Sigmund CD and Lazartigues E. . Brain-selective over-expression of human Angiotensin Converting Enzyme 2 attenuates neurogenic hypertension. Circulation Research. 106:373-382; 2010. (Selected for the Cover) PMID: 19926873.
  • Hans C, Feng Y, Naura A, Troxclair D, Naura AS, Zerfaoui M, Ju J, Kaye AD, Lazartigues E, DeClerck YA, and Boulares AH. . Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. Cardiovascular Pathology. 20(2): e56-68, 2010. PMID: 20434371.


  • Xia H, Feng Y, Obr TD, Hickman PJ and Lazartigues E. . AT1 receptor-mediated reduction of ACE2 activity in the brain impairs baroreflex function in hypertensive mice. Hypertension. 53(2):210-6; 2009. PMID: 19124678.
  • Hans C, Feng Y, Naura A, Zerfaoui M, Rezk B, Xia H, Kaye A, Matrougui K, Lazartigues E and Boulares H. . Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE-/- mice: effects on eNOS and oxidative stress. PLoS One. 4(10): e7430; 2009. PMID: 19823587.
  • Zhang X, Wang G, Dupré DJ, Feng Y, Robitaille M, Lazartigues E, Feng YH, Hébert TE, and Wu G. . Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor. Journal of Pharmacology and Experimental Therapeutics. 330(1):109-17; 2009. PMID: 19357319.
  • Xu W, Yi L, Feng Y, Chen L and Liu J. . Structure insight into the activation mechanism of human pancreatic prophospholipase A2. The Journal of Biological Chemistry. 284: 16659-16666; 2009. PMID: 19297324.


  • Feng Y, Yue X, Xia H, Bindom SA, Hickman PJ, Filipeanu C, Wu G and Lazartigues E. . Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation. Circulation Research. 102(6):729-36; 2008. PMID: 18258853.
  • Park S, Bivona BJ, Feng Y, Lazartigues E, and Harrison-Bernard LM. . Intact renal afferent arteriolar autoregulatory responsiveness in db/db mice. American Journal of Physiology - Renal Physiology. 295:F1504-1511; 2008. PMID: 18753291.


  • Lazartigues E, Feng Y and Lavoie J. . The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases. Current Pharmaceutical Design.13: 1231-1245; 2007. PMID: 17504232 (Review).


  • Feng Y, Feng Y, Liao X, Zhu X, Zhou Q, Zeng Z and Ma Q. . Characterization of a monoclonal antibody that antagonizes the function of human endostatin. Hybridoma. 24(1): 42-49; 2005. PMID: 15785208.
  • Feng Y, Feng Y, Zhu X and Ma Q. . Inhibition of rhEndostatin on corneal neovascularization. Chinese Ophthalmic Research. 23(1): 12-14; 2005.


  • Feng Y, Feng Y, Zhu X, Dang Y and Ma Q. . Alkali burn causes aldehyde dehydrogenase 3 A1 (ALDH3A1) decrease in mouse cornea. Molecular Vision. 10: 845-850; 2004. PMID: 15547490.
  • Wu G, Feng Y, Zhang X, Feng Y, Qing Z, Lu L, Li S and Ma Q. . Serum Endostatin Levels in Patients with Primary Hepatocellular Carcinoma. Chongqing Medicine. 33(12): 1843-1847; 2004.
  • Feng Y, Zhang Y, Zhu X, Feng Y and Ma Q. . Soluble expression of human endostatin in E.coli. China Biotechnology. 24(9): 943-947; 2004.
  • Feng Y, Feng Y, Zhu X, Dang Y, Ma Q, Zhou Q and Zeng Z. . The expression of MMP2, MMP9 and VEGF in alkali-burn induced mouse corneal neovascularization. Letters in Biotechnology. 15(6):561-565; 2004.


  • Feng Y, Feng Y and Ma Q. . New progresses in B-cell Activating Factor. Chemistry of Life. 23(4): 265-267; 2003. (Review).
  • Feng Y, Feng Y, Zhang Y, Ren L, Zeng Z and Ma Q. . Preparation and identification of the monoclonal antibody against human endostatin. Chinese Journal of Cellular and Molecular Immunology. 19(6): 580-582; 2003. PMID: 15182655.


  • Feng Y and Zeng Z. . Mechanism of Alternative Lengthening of Telomeres. Clinical Biochemistry and Laboratory Medicine, Foreign Medical Sciences. 23(4): 212-213; 2002 (Review).

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