The Dagda Lab Published in Journal of Parkinson's Disease

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Congratulations to The Dagda lab for its recently published article in the Journal of Parkinson's Disease showing how a nootropic compound can cure rats with Parkinson's disease. 

Ruben K. Dagda, Ph.D., associate professor of pharmacology, Emmanuel Vazquez Mayorga, Ph.D., Raul Dagda, M.S., and Bridget Martinez, M.D. Ph.D., co-published a research manuscript chapter titled "Intraperitoneal administration of forskolin reverses motor symptoms and loss of midbrain dopamine neurons in PINK1 knockout rats in the Journal of Parkinson's disease.

Overall, this study shows that forskolin, a labdane diterpenoid that activates Protein Kinase A, can reverse Parkinson's disease in a genetic rat model of Parkinson's.

The authors investigated the neuroprotective effects of forskolin in Parkinsonian rats (PINK1 knockout rats). They found giving forskolin intraperitoneally reversed motor symptoms (e.g. loss of balance) and midbrain dopamine neuron loss in symptomatic Parkinsonian rats. Using a Seahorse Bioanalyzer available at the Mick Hitchcock Proteomics Center, the authors discovered that giving Parkinsonian rats forskolin increased brain energy production and reversed muscle fatigue. In Parkinsonian rats, forskolin was found to be significantly "better" than standard-of-care Levodopa at reducing symptoms and chronic fatigue. 

The authors hope to transition the preclinical study to clinical studies in humans soon.

This study was funded by NIH grant 5R01NS105783-02, the William Pennington Foundation, and CONACYT (Mexico). The technology supporting the use of forskolin and other nootropic agents in a formulation is supported by patent publication US20210220322A1 (pending granting of a patent).

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Released: Monday March 7, 2022 @ 5:00 PM