Pharmacology 750

Cellular and Molecular Mechanisms of Excitability

This course will focus on the molecular biological, biochemical and biophysical characteristics of voltage- and ligand-gated ion channels, and other ion transport proteins in a variety of excitable cells. The course will begin with a description of basic cable theory, conventional electrophysiological techniques and classical "Hodgkin & Huxley" analysis of ion channels in axonal membranes and trace the development of new biophysical and molecular biological methods for the study of ion channels. Individual lectures will then focus on studying the different classes of ion channels, including potassium, sodium, calcium and chloride channels. The objective will be to describe the physiological and pharmacological function of each type of ion channel and to examine the relationship between biophysical properties and protein structure. Finally, several classes will examine the ionic basis of excitability in selected types of excitable membranes, including nerve, cardiac, skeletal and smooth muscle. This class is open to all graduate students who have completed introductory Pharmacology or Physiology courses and obtained instructor approval.

For Information

Normand Leblanc, Department of Pharmacology, course coordinator
Manville #9; (775) 784-1420;
Text: Hille, B., Ion Channels of Excitable Membranes
Sinauer Associates, Sunderland Ma., 3rd ed., 2001

Catalog Description for PHAR 750