Pharmacology News

Department of Pharmacology

Kudos 

Earley published in the Proceedings of the National Academy of the Sciences

A recent article from the laboratory of Scott Earley, Ph.D., department of pharmacology, appeared in Proceedings of the National Academy of Sciences. The article, "Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility" was co-authored by Harry A. T. Pritchard, Ph.D., Caoimhin S. Griffin, Ph.D., Evan Yamasaki, Pratish Thakore, Ph.D., Conor Lane, and Adam S. Greenstein, Ph.D.. Congratulations!

Mastick published in the Journal of Biological Chemistry

A recent article from the laboratory of Cynthia Corley Mastick, Ph.D., department of pharmacology, appeared in a special issue of the Journal of Biological Chemistry. The article, "A high-throughput chemical-genetics screen in murine adipocytes identifies insulin-regulatory pathways" was co-authored by Paul Duffield Brewer, Ph.D., and Irina Romenskaia, Ph.D. The paper describes assays to identify and validate small molecules that enhance or inhibit insulin action. Congratulations!

Dr. Robert Harvey

Recent Grants and Publications for Dr. Robert Harvey:

Grants:
National Institutes of Health R01 HL145778
Mechanisms of cAMP Compartmentation in Cardiac Myocytes
15 January 2019 - 31 December 2022

Publications:
Johstone,T.B., S.R. Agarwal, R.D. Harvey, and R.S. Ostrom. cAMP signaling compartmentation: Adenylyl cyclases as anchors of dynamic signaling complexes. Molecular Pharmacology, 93:270-276, 2018. doi:10.1124/mol.117.110825.

Harvey, R.D. and A.O. Grant. Agents Used in Cardiac Arrhythmias. Chapter 14 In: Basic and Clinical Pharmacology, 14th edition. B.G. Katzung, S.B. Masters, A.J. Trevor eds. McGraw Hill-Lange (New York) 2018.

Agarwal, S.R., J. Gratwohl, M. Cozad, P.-C. Yang, C.E. Clancy, and R.D. Harvey. Compartmentalized cAMP signaling associated with lipid raft and non-raft membrane domains in adult ventricular myocytes. Frontiers in Pharmacology, 9:332, 2018. doi: 10.3389/fphar.2018.00332

Dr. Heather Burkin

Dr. Heather Burkin has been invited to attend the 2019 AAMC Early Career Women Faculty Leadership Development Seminar

This popular and highly interactive seminar provides women at the assistant professor level with the knowledge and skills necessary to navigate the academic medicine enterprise as well as continue on the path to leadership.

This three and a half-day seminar is designed for women physicians and scientists holding medical school appointments and in the early stages of leadership positions within their discipline, department or institution. The seminar will present a foundation for modeling leadership behavior, assist in creating individual leadership goals, and provide an opportunity to receive mentorship on career-building skills, such as a personal statement and CV development. Participants will gain insights into the realities of building a career in academic medicine and science and will explore various paths to leadership within the academic health enterprise.

Throughout the seminar, areas of focus include: expanding self-awareness and leadership styles, improving communication and developing strategies for leading effective teams, navigating gender dynamics in the workplace, improving financial acumen and strategic planning, and more. The seminar also focuses on expanding a network of colleagues with the facilitation of peer discussion, large and small-group sessions, and the opportunity to reflect on how new skills and strategies can be applied upon the return to their institution. Additionally, there is an emphasis on establishing personal organizational skills and wellness practices to serve as a foundation for success as women advance to higher faculty ranks and leadership positions.

Seminar faculty from schools throughout the United States and Canada have been chosen for their specialized knowledge in particular areas and demonstrated leadership capabilities. They offer valuable information, inspiring stories, and practical advice to support career advancement.

Dr. Sue Liebman

Dr. Susan Liebman has had a paper published in J Mol Biol. Respiration Enhances TDP-43 Toxicity, but TDP-43 Retains some Toxicity in the Absence of Respiration, is an invited Member Review committee, Institute of Molecular Biology Academia Sinica, Taipei, Taiwan Nov. 2019. She is also an invited speaker at CSH meeting "Yeast Research:Origins, Insights, Breakthroughs" Oct. 2019 . Lastly, was an Ad Hoc Member National Institutes Diabetes and Digestive and Kidney Diseases Board of Scientific Counselors, Oct. 2018

Dr. Iain Buxton has cured breast cancer—in mice. (with audio)

Still, Buxton and his team, at the UNR Department of Pharmacology, believe they've cracked the code of metastasis. In the context of breast cancer, that means they've figured out how cancer cells from the breast move to other parts of the body, where they develop into terminal cancer. Buxton says they now understand how that migration works, and what tends to trigger tumor growth, and have pinpointed two drugs that effectively stop it from happening.

KNPR: New Discovery in Breast Cancer Fight

Researchers at the University of Nevada, Reno have made some significant strides into breast cancer and how it metastasizes. And with the help of a new microscope that the state has helped fund through settlements with pharmaceutical companies, they expect to excel that research toward a cure. "The things I need to find out just can't be found out in any other way," said Dr. Iain Buxton, who heads up that research.

Breast Cancer Breakthrough (video)

Researchers at the University of Nevada, Reno have made some significant strides into breast cancer and how it metastasizes. And with the help of a new microscope that the state has helped fund through settlements with pharmaceutical companies, they expect to excel that research toward a cure. "The things I need to find out just can't be found out in any other way," said Dr. Iain Buxton, who heads up that research.

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