Department of Pharmacology
Faculty and Staff

Regulation of ion channels and cell signaling by autonomic nervous system in mammalian heart.

Role of integrins and integrin signaling in neuromuscular development and disease, and integrin signaling in vascular smooth muscle cell plasticity.

Signaling pathways that regulate stretch induced activation of the human uterine myometrium. Development of therapeutic targets for the treatment of preterm labor.

Receptor-signal transduction in cardiac and smooth muscle cells. Role of receptor-stimulated phosphoinositide metabolism; agonist-specific regulation of cyclic nucleotide action; role of adenyl purines in myometrial function and hormonal regulation of endothelial cell contractile factors.

Interaction of electromagnetic fields with excitable cells; exploring the potential for nanosecond duration electric pulses of high intensity as a new, bioelectric approach for stimulating neural cells.

Regulation of mitochondrial biology and bioenergetics by serine/threonine kinases and phosphatases in neurons and in cardiac cells; new signaling pathways that promote synaptic connectivity; development of alternative therapies to reverse mitochondrial dysfunction in age-related brain diseases.

Transient receptor potential (TRP) channels in endothelial and smooth muscle cell function.

Neural cardiovascular physiology; the neural mechanisms of hypertension and other cardiovascular diseases including diabetes and obesity.

Cardiac electrophysiology, cell signaling, and ion channel regulation.

Role of ion channels in the regulation of excitation-contraction coupling of cardiac and vascular smooth muscle cells in health and disease.

In addition to her role as the Associate Dean, Dr. Singer is an Associate Professor in the Pharmacology Department, continuing her research on the molecular mechanisms contributing to inflammatory lung disease.

Molecular mechanisms of leukocyte adhesion and inflammation.