Dorthy Hudig

dorthy-hudig

Dorothy Hudig, Ph.D.

Professor
Mechanisms of lymphocyte-mediated cytotoxicity; Antibody-dependent cell-mediated cytotoxicity by natural killer cells

Summary

Professional Biography

  • 1991 - present:  Professor, Dept. of Microbiology and Immunology, University of Nevada, Reno
  • 1989: Tenured, Associate Professor, School of Medicine and College of Agriculture, University of Nevada, Reno
  • 1984: Associate Professor, Department of Microbiology, School of Medicine and School of Veterinary Medicine, University of Nevada, Reno
  • 1979 - 1984: Associate Member, and Assistant Research Biochemist I-III, University of California, San Diego Cancer Center
  • 1977 - 1979: Postdoctoral fellow, Department of Medicine & Cancer Center, University of California, San Diego, with John Mendelsohn, M.D.

Courses Taught

  • Medicine 636 (Block 6, “Foundations and Principles of Medical Science II”), Basic Immunology lectures for second year medical students (2013-2017)
  • Medicine 637 (Block 7, “Whole Body”), directed together with Jaren Blake, MD; cancer immunology and autoimmunity of arthritis lectures, for second year medical students (2013-2017).
  • Medicine 640 (Block 10, “Whole Body”), immunology lectures, mucosal immunology for second year medical students (2014-2016).
  • Physician Assistant Program PA620, 16 hr section “Immunology for physician assistants”, (2018).
  • Medical Clinical Problem Solving I ( (Fall 2010, Spring 2011, Fall 2011, Spring 2012). Team-based learning from clinical problems.  Paired with Thomas J. Hunt, MD, family practice.
  • Microbiology 490, Independent Study
  • Microbiology 780, Introduction to Cellular Immunology
  • Microbiology 787, Cell and Molecular Biology of Cancer
  • Cell and Molecular Biology 799, Ph.D. Thesis Advisement, 9 students
  • Biotechnology or Microbiology or Cell and Molecular Biology 799,S. Thesis Advisement, 7 students
  • Microbiology or Cell and Molecular Biology 701/702, Graduate Student, Research Rotation (3 credits), Faculty advisor

Research Interests

Natural killer and cytotoxic T lymphocytes can kill tumor and virus-infected cells by means of pore-forming proteins that are released from granules of the killer lymphocytes.  A significant problem is that many of the NK cells stop after killing after destroying only one ‘target’ cell rather than going on to kill multiple target cells.  We are addressing the issues of how to generate serial killers.  These serial killers would be highly desirable against solid tumors.  My laboratory was among the first to recognize the role of the serine protease called granzymes in killing (1980) and is now characterizing how they affect serial killing.

The Hudig lab maintains an interest in myalgic encephalomyelitis/chronic fatigue syndrome, (ME/CFS), focusing on monocyte and NK cell cooperation in ADCC. 

Current Lab Members

  • Michael Guglielmo, Staff Research Associate II
  • Alexander P. Sung, MD-PhD student
  • Lydia Navarette-Galvan, Microbiology honors undergraduate, NURA scholar

Past Lab Members

  • John Adlish, Ph.D.
  • Janine Allison
  • Vincent Anderson
  • Bryce N. Alves, Ph.D.
  • Christy Bethley
  • Tejal Bhatt
  • Leticia Cano, Ph.D.
  • Alex Cardenas, M.D.
  • Kathleen Carine, Ph.D.
  • Chaudhuri, Ph.D.
  • Christopher Clark
  • Ron Cornwell, M.D.
  • Christina Damron
  • Michael Djobadze
  • Jillian Edelnant
  • Vicky Elliott
  • Gerald Ewoldt, Ph.D.
  • Stephanie Fraser, Ph.D.
  • Ruth Gault, Ph.D.
  • Jason George
  • Amy Lee Ginder
  • Will Hallett, Ph.D.
  • Adam Henner, JD
  • Nathan Hiatt,
  • Yongmoon Han, Ph.D.
  • Jason Hedges
  • Patricia Huerta
  • Reza Karimi, Ph.D.
  • Shaparak Kamarei, M.D.
  • Linda Katzenmayer
  • Andrew Kuhn, Ph.D.
  • Jeff Leong, MD-Ph.D.
  • Aaron McDaniel. M.D.
  • Ryan McKinney
  • Joshua C. Meier
  • Robyn Mellender, JD
  • Minghui Li
  • Lila Murphy
  • Haiyan Liu, MD., Ph.D.
  • Daisy Narayan, Ph.D.
  • Dale Netski, Ph.D.
  • Tim Pickett
  • Corey Pine
  • Liza Rechetnik
  • Carol Rice, M.D.
  • Edward Rich, M.D.
  • Amy Schneck
  • Mario Silva
  • Dennis Small, M.D.
  • David Tamang, Ph.D.
  • Jia-Jie Jennifer Tang
  • Bert Tardieu, M.D.
  • Suhani Thaker
  • Maria Tinangon
  • Lisa Tran
  • Lory Minning Walls
  • Ming Te Wang
  • Richard Waters
  • Ulrike Winkler, Ph.D.
  • Susan L.  Woodard, Ph.D.
  • Sunny Xiong
  • Susan Zunino, Ph.D.

Education

  • 1977 - Ph.D., Biology/Immunology, University of California, San Diego
  • 1968 - B.A., Biology, cum laude, Bryn Mawr College