Summary
Research in the Brett laboratory is focused on elucidating the molecular mechanisms used by Burkholderia pseudomallei, the causative agent of melioidosis, to evade clearance by host defenses. In particular, we are interested in determining how the lipopolysaccharides and capsular polysaccharides expressed by this organism contribute to this process. Our laboratory has over 25 years of experience working with this important bacterial pathogen and has gained significant expertise in areas relating to Burkholderia genetics, pathogenesis, host-pathogen interactions, carbohydrate purification/characterization, glycoconjugate synthesis and the analysis of humoral/cellular immune responses. The main goal of our research is to identify correlates of antigen-induced immunity against B. pseudomallei and use this information to develop safe, affordable and effective melioidosis vaccines.
Education
- B.Sc., Biochemistry, University of Victoria
- Ph.D., Bacterial Pathogenesis, University of Calgary